Name | domiphen bromide |
Synonyms | bradoral bradonit bradasol bradosol bradosolbromide domiphen bromide dodecyldimethyl(2-phenoxyethyl)-ammoniubromide dimethyldodecyl(2-phenoxyethyl)-ammoniubromide beta-phenoxyethyldimethyldodecylammoniumbromide N,N-dimethyl-N-(2-phenoxyethyl)dodecan-1-aminium bromide |
CAS | 538-71-6 |
EINECS | 208-702-0 |
InChI | InChI=1/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1 |
InChIKey | OJIYIVCMRYCWSE-UHFFFAOYSA-M |
Molecular Formula | C22H40BrNO |
Molar Mass | 414.46 |
Density | 1.1411 (rough estimate) |
Melting Point | 117-119 °C (lit.) |
Water Solubility | Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene. |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Merck | 14,3415 |
BRN | 3922742 |
Storage Condition | Inert atmosphere,Room Temperature |
Sensitive | Hygroscopic |
Refractive Index | 1.5570 (estimate) |
MDL | MFCD00011769 |
Use | Ent medicine, can be used for oral cavity and skin Disinfection |
In vitro study | Recombinant synthetase (ISPD) was observed to be sensitive to Domiphen Bromide (DMB) by an ISPD activity assay. The inhibitory effect of DMB on ISPD can be confirmed by the newly established high-throughput screening system and traditional enzyme kinetic analysis. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | BQ2030000 |
TSCA | Yes |
Hazard Class | 6.1 |
Packing Group | III |
This product is N, n-dimethyl-ak2-phenoxyethyl)-l-dodecanammonium bromide monohydrate. The content of C22H40BrNO shall not be less than 98.0% calculated as dry product.
after drying at 80°C under reduced pressure for 5 hours, the product is immediately measured according to law (General rule 0612), and the melting point is 108-118°C.
take 0.20g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 5.0~7.0.
take this product l. After adding 10ml of water to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 2 Turbidity standard solution (General rule 0902 method 1); If it is colored, it shall not be deeper in comparison with the yellow No. 1 Standard Colorimetric solution (General rule 0901 first method).
take 25ml of the solution under the content determination item, and use hydrochloric acid titration solution (0.lmol/L) 10ml instead of sodium hydroxide titration solution (0.lmol/L) 10ml, the same method of operation. Calculate the difference between the volume of potassium iodate titrant (0.05mol/ L) consumed in the determination and non-quaternary ammonium titration for each lg of mephene, and shall not be greater than 0.5.
take this product, dry to constant weight at 80°C, weight loss shall not exceed 5.0% (General rule 0831).
not more than 0.1% (General rule 0841).
take 2.0g of this product, accurately weigh it, put it in a 100ml measuring flask, add water to dissolve and dilute it to the scale, take 25ml from the precision child, put it in a separatory funnel, add chloroform 25ml and sodium hydroxide titration solution (0.1 mol/L)10ml, Add 10ml of new 5% potassium iodide solution, shake, stand still to make layers, separate the water layer and wash with chloroform shaking for 3 times, 10ml each time, remove the chloroform layer, remove the water layer into a 250ml plug Erlenmeyer flask, rinse the separatory funnel with about 15ml of water for 3 times, incorporate the eluent into the Erlenmeyer flask, add 40ml of hydrochloric acid, and let cool, titrate to light brown with potassium iodate titration solution (0.05mol/L), add 2ml of chloroform, continue titration and shake vigorously until the red color of chloroform layer disappears; 10ml of the newly prepared 5% potassium iodide solution was accurately measured, 20ml of water and 40ml of hydrochloric acid were added, and the same method was used for blank test.
for each 1 ml potassium iodate titration solution (0.05mol/L) corresponding to 41.45mg of C22H40BrNO.Disinfection antiseptic.
light shielding, sealed storage.
This product shall contain 85.0% ~ 115.0% of the labeled amount of meifene (C22H40BrNO • H20).
This product is white to slightly yellow drop pills.
should comply with the relevant provisions under the pill (General rule 0108).
The same dose of miphene.
20mg
light shielding, sealed storage.